Doctoral candidates
DC6/ The project was discontinued as of March 2025.
DC8/ Ulrich Pototschnig – First-principles approach to exchange effects in CISS – Hamburg University
Pravya P. Nair – Université Libre de Bruxelles
Novel molecular systems for high CISS effect
Biography
I have completed my Integrated Master’s degree in Chemistry from Institute for Integrated Programmes and Research in Basic Sciences (IIRBS), Mahatma Gandhi University Kottayam, Kerala in India. My Bachelors mini project at IIRBS on the isolation of Garcinia acid was guided by Prof. Dr. Ibrahim Ibnusaud. In 2019, I was selected as an IISER Mohali, Summer Intern fellow. My masters review project on Ni catalysts in Sonogashira coupling and fluoro methylation reactions was supervised by Dr. Anilkumar Gopinathan, MG University. I had a 4-month internship at NIT Calicut to complete my master’s thesis from the lab of Dr. Chinna Ayya Swamy P that focused on the development of benzimidazole based NHC catalysts. Later, I worked as a Project Associate at the Central Drug Research Institute, Lucknow to develop pyrazolo-indole based nucleosides under the supervision of Dr. Kishor Mohanan to study their antiviral activity. In my spare time I love learning about traditional mural paintings, reading fiction books or watching movies.
Doctoral project
Within the CISSE project, my research work at Université Libre de Bruxelles is supervised by Prof. Yves Geerts. My project is based on the design, synthesis of novel molecular systems particularly TCNQ derivatives to study the CISS effect. These molecules are anticipated to open up potential application of CISS in the field of Organic semiconductors and Spintronics. The CISS measurements will be done eventually from HUJI and further studies at WWU.
Project status (July 2025)
To date, the CISS effect has been exclusively measured on closed-shell structures. To increase the molecular diversity in understanding CISS, my project aims to develop chiral electron acceptors that can give open-shell structures such as monoradical and diradical anions in presence of an electron donor.
Since its first report in 1962, the electron acceptor tetracyanoquinodimethane (TCNQ) and its derivatives have garnered much attention due to its ability to form conducting charge-transfer (CT) complexes with various donors. The CT complex of tetrathiafulvalene (TTF) and TCNQ is known to be highly conducting and has found its application in various fields.
Over the past year and a half, I have been working on the design and synthesis of chiral TCNQ derivatives. The optimisations of synthetic routes to access chiral TCNQs and TTF donor are ongoing at ULB and during my secondment at Symeres. I am grateful to the continuous guidance and support of my supervisor Prof. Yves Geerts, Dr. Victor Laureys and lab members at ULB and Symeres. In the next phase of my project, chiral TCNQ-TTF will be fabricated onto Au surface for carrying out CISS measurements at WWU.
These novel chiral TCNQs can behave as a potential redox active n-type semiconductor that can contribute to the general understanding of the CISS effect during charge transport and can potentially open new avenues for the introduction of organic materials in spintronic devices.
Chiral Acceptor-Donor Complex for studying the CISS effect
Mampi Biswas – Université Libre de Bruxelles
Enantioselective preferential physisorption, chemisorption, and dimerization at spin-polarized interfaces
Biography
I am a PhD student at the Laboratory of Polymer Chemistry at Université libre de Bruxelles, serving as the DC2 of the CISSE project. I embarked on my doctoral journey in August 2023 under the supervision of Professor Yves H. Geerts. I completed my bachelor’s degree in chemistry Honours at the University of Kalyani, West Bengal, India, in 2021. Subsequently, I joined the Indian Association for the Cultivation of Sciences (IACS), Kolkata, West Bengal, India, for my master’s degree. After completing a master’s thesis in the laboratory of Assistant Professor Dr. Anindita Das, specializing in Polymer Science and Soft Matter, I obtained my master’s degree in chemical sciences.
My research during this period focused on two projects: the synthesis and self-assembly study of functional degradable amphiphilic polyesters and the crystallization-driven controlled two-dimensional assemblies from functional Poly-L-Lactides.
My doctoral project revolves around the study of ‘Enantioselective Preferential Physisorption, Chemisorption, and Dimerization at Spin-Polarized Interfaces.’ Currently, I am working on synthesizing enantiomeric molecules with a functional group that adsorbs or reacts differently on spin-polarized metallic surfaces. This research aims to understand how spin controls the fate of reduced or oxidized species on spin-polarized electrodes.
Outside of academia, I have a passion for singing, love to travel worldwide, and enjoy tasting diverse foods, despite being a vegetarian.
Doctoral project
My project is about to study ‘Enantioselective preferential physisorption, chemisorption, and dimerization at spin-polarized interfaces’ as DC2 in in the CISSE group. My work is to design and synthesize different molecular systems with functional group having reactivity on spin-polarized interface and adsorb differently on spin-polarized metallic surfaces and that spin controls the fate of reduced or oxidized species on spin-polarized electrodes. 1H NMR, 13C NMR and mass spectrometry (MS) will be used to characterize each molecular system. Specially, we are looking for developing a thiol or dithiol functionalities as an active group, in our molecular designs (enantiomers) as they have strong interaction on gold (Au (111)) surface through van der Waals interactions and easy production through gas-phase or solutions. These molecules can form self-assembled monolayers (SAMs) on top of the spin-polarized metallic surface. The assessment of enantiomeric excess will be conducted locally using scanning tunnelling microscopy (STM) for systems with a preference for physisorption and chemisorption on the metallic surface. The atomic force microscopy (AFM) analysis will be performed to investigate more about the self-assembly of those dithiol compounds. The adsorption kinetics of the substances will be investigated using quartz microbalance. Enantioselective oxidative coupling of prochiral monomers to produce chiral dimers will be carried out using spin-polarized electrodes. The study will utilize conglomerate-forming atropisomers and conformers with different racemization barriers to investigate their nucleation on a variety of spin-polarized substrates. The correlation between enantiomeric excess and factors such as molecular systems, crystallization conditions, and spin-polarization will be explored. Additionally, the interactions between enantiomers and spin-polarized surfaces will be examined through contact angle measurements.
Project status (July 2025)
The project unravels how chiral molecules interact with spin-polarized surfaces to induce enantioselective adsorption depending on the structure-property relationship. Over the past one and a half years, the work has progressed through three intertwined stages: molecular design and synthesis, self‐assembled monolayer (SAM) fabrication and characterization, and preliminary spin‐polarization measurements.
Molecular design and synthesis (Performed at ULB)
A diverse set of thiol‐functionalized chiral molecules depending on chirality, functionality and dipole moment was successfully synthesized in both racemic and enantiopure forms for binding with the Au and Au/Ni surfaces. Each step was optimized to yield high enantiomeric excess (>97 %) and high purity, as confirmed by spectroscopic analysis, thermal analyses and high-performance liquid chromatography (HPLC) measurements. These efforts have provided a robust library of chiral adsorbates for surface‐science studies.
Different dipole moments of enantiopure thiol-functionalized chiral molecules when adsorbed on the metal surface (pillow effect).
Fabrication and structural characterization of SAMs (Performed at KUL)
With a library of chiral adsorbates in hand, self-assembled monolayers were grown on atomically flat gold substrates. By immersing a gold substrate in a dilute solution under controlled conditions, uniform films formed. High-resolution scanning tunneling microscopy (STM) images confirmed that monolayers from single enantiomers produced well-ordered domains, whereas those from racemic mixtures yielded only disordered patches. Atomic force microscopy (AFM) scratching experiments measured the ordered layer’s thickness, which matched the expected molecular dimensions and demonstrated reproducible film formation across different solvents.
Probing spin-selective behaviour (Performed at KUL)
Spin polarization study of the enantiomers on magnetized spin polarized surface.
This study demonstrates how chiral layers affect electron spin. Initial scanning tunneling spectroscopy (STS) experiments compared chiral films on non-magnetic (Au/Mica) and ferromagnetic (Au/Ni/Mica) substrates under applied magnetic fields. I-V measurements revealed that the R- and S-enantiomers produced spin polarizations of opposite sign.
Collaborative milestones
Throughout this period, targeted secondments have enriched the project’s expertise: a first secondment at KU Leuven, in Prof. Steven De Feyter’s group, provided advanced microscopy training, and an upcoming visit to the University of Pittsburgh, in Prof. David Waldeck’s group, will focus on adsorption-kinetics instrumentation. Regular workshops and data exchanges across the network have helped align protocols and troubleshoot challenges in real time.
Looking ahead
Building on these foundations, the next phase will expand the surface studies to additional chiral scaffolds, explore the potential for directing enantioselective crystallization at interfaces and contact angle measurements on spin polarized surface for enantiomers depending on real time in the group of Prof. Patricia Losada Pérez at ULB. By systematically linking molecular structure, film architecture, and spin response, the DC2 project aims to deliver a comprehensive picture of how molecular chirality can be harnessed to control electron spin – a key step toward future enantioselective technologies.
Lekshmi Aravindan Geetha – KU Leuven
Visualisation of the impact of spin-polarized surfaces on (supra)molecular physisorption and chemisorption at the nanoscale
Biography
I am a doctoral student in the esteemed group of Prof. Steven De Feyter at KU Leuven, Belgium. I hail from a small town in Kerala, India, also known as “God’s own country” because of its beautiful landscapes. I did my Bachelor’s and Master’s degree in Chemistry from Amrita Vishwa Vidyapeetham in Kollam, Kerala, India. Driven by a deep passion for the subject, I worked for a short period as a student researcher in Prof. Saritha Appukuttan’s lab. During this time, my work focused on the synthesis of nanocatalysts and conducting green photocatalytic polymerizations with these nanocatalysts.
Subsequently, I joined the De Feyter group (SDF) as a PhD student. My research focusses on the fascinating field of Chirality-induced Spin Selectivity Effect. This involves the use of scanning probe microscopy (SPM), i.e. scanning tunneling microscopy (STM), and atomic force microscopy (AFM) under ambient conditions at the solid-liquid interface to study the supramolecular physisorption and chemisorption processes occurring at the spin-polarized interfaces. In the course of the research, I aspire to enhance my scientific knowledge and skills through collaborations and research stays. I believe that I can not only deepen my expertise, but also contribute to the advancement of our field and make valuable connections within the global community.
In addition to my academic pursuits, I am also a singer with a passion for reading, travelling and culinary experiences.
Doctoral project
Scanning probe microscopy (SPM) techniques such as scanning tunnelling microscopy (STM) and atomic force microscopy (AFM) are used to study the surface chemistry of molecules, i.e., exploring the adsorption, ordering and self-assembly, dynamics, reactivity, and electrical properties of molecules adsorbed on solid surfaces. The research project majorly focusses on the use of SPM under ambient conditions at the solid-liquid interface for probing the supramolecular physisorption and chemisorption processes occurring at spin-polarised interfaces and it also includes the study of the influence that the interface has on the adsorption processes.
The project’s key areas of interest involve preparing and analysing chiral films of various thickness, studying spin-induced enantioselective adsorption process and spin-induced deracemization at the level of the formation of self-assembled molecular networks at the liquid-solid interface. Also, the research aims to induce and probe the enantioselective chemisorption with molecular resolution using SPM. Another major aspect of the research project is to functionalise the STM tips with chiral molecules and then exploring the potential of the chiral functionalized STM tips on the imaging of chiral/achiral interfaces. The project will initially focus on investigating the self-assembly of liquid crystals. This includes the study of induction of chirality in the self-assembly of the liquid crystal using magnetic field, sergeant-soldiers approach and also to study the transmittance of chirality to the bulk of the liquid crystal using STM and non-linear optical spectroscopy.
Project status (July 2025)
Visualization of the impact of spin-polarized surfaces on (supra)molecular physisorption and chemisorption at the nanoscale
Over the past one and a half years, my doctoral research at KU Leuven was focused on understanding the influence of molecular chirality and supramolecular organization at interfaces on fundamental properties such as electron transport. I am a part of the Marie Skłodowska-Curie Actions Doctoral Network, CISSE, which brings together diverse approaches to explore spin-selective phenomena in chiral systems, particularly the Chiral-Induced Spin Selectivity (CISS) effect, where chiral molecules exhibit a preference for conducting electrons with a specific spin orientation.
A significant part of my work involves studying the self-assembly behavior of prochiral liquid crystal molecules such as 4′-Octyl[1,1′-biphenyl]-4-carbonitrile (8CB) and 4′-Dodecyl-[1,1′-biphenyl]-4-carbonitrile (12CB), on atomically flat surfaces. These molecules form chiral domains (left-handed and right-handed domains) on Highly Oriented Pyrolytic Graphite, which can be visualized by Scanning Tunneling Microscopy (STM) at ambient conditions (Figure 1). These molecules can serve as a model to explore the influence of chiral auxiliary molecules in guiding the systems to form homochiral surfaces. We successfully observed induction in chirality in the monolayers of 12Cb molecules on the addition of chiral auxiliary. This helps to study the transfer of chirality at the molecular level.
Figure 1. Chemical structures of 8CB and 12CB. Scanning tunneling microscopy images of self-assembled molecular network of 12CB (left-handed and right-handed) on HOPG.
In parallel, I have been also studying the spin polarization of chiral molecules adsorbed on surfaces, with the aim of understanding how intrinsic molecular chirality can influence spin-selective electron transmission. This work contributes to the broader effort of quantifying spin polarization induced by supramolecular chirality and aims to identify structural parameters that govern spin-selective transport at the interface.
To complement these experimental studies, I completed a three-month secondment at the University of Hamburg in the group of Prof. Carmen Herrmann, where I focused on computational modelling of interactions between chiral STM tips and surface-adsorbed molecules to understand the influence of chiral tips in tunneling current. surface-adsorbed molecules to understand the influence of chiral tips in tunneling current. The secondment period was both productive and enriching, providing valuable opportunities to deepen my understanding, develop new skills, and engage in fruitful collaborations that have significantly supported the progress of my research.
In the next phase of my research, the focus will shift towards investigating the spin polarization of chiral molecules adsorbed on surfaces. This involves exploring how physisorption as well as chemisorption can influence spin-selective electron transport. By systematically varying the surface conditions and molecular arrangement, this work aims to provide deeper insight into the factors that govern spin polarization at chiral interfaces.
I would like to sincerely thank my supervisor, Prof. Steven De Feyter for his invaluable guidance, mentorship, and continuous support throughout my research. I am also grateful to Dr. Kunal S. Mali and Dr. Shammi Rana for their insightful discussions and encouragement, which have played an important role in shaping the direction of my work.
Maria-Cristina Ghetu – Weizmann Institute of Science
Elucidation of spin-controlled bio-related interactions
Biography
In 2019, I achieved a Bachelor of Science in chemistry from the University of Bucharest, concentrating my thesis on electroanalytical chemistry. Concurrently, I engaged in an Erasmus program in Gdansk, Poland.
Continuing my academic journey, I pursued the Master of Science program “Chemistry of Advanced Materials” at the same university. My thesis was part of the “Green Chemistry of Advanced Materials” international collaboration between the University of Bucharest and the Norwegian University of Science and Technology. This research involved developing a biocatalyst for the valorization of monoterpene.
After my master’s degree, I conducted research at the University of Bucharest, focusing on characterizing biomimetic MOFs with transition metal centers and proposing potential catalytic applications.
Throughout both my academic pursuit during my master’s degree at the University of Bucharest and my professional experience thereafter, I gained extensive expertise in employing diverse characterization methods (IR, UV-VIS, XRD, XPS, NMR). This allowed me to assess structure-property relationships and devise more efficient catalytic processes, ultimately presenting these advancements at an international conference.
Doctoral project
My ongoing research centers on exploring how electron spin influences various bio-related interactions, spanning from protein-protein associations to enzyme kinetics. Recent advancements in understanding the chiral induced spin selectivity (CISS) effect highlight the potential of manipulating electron spin, despite its complexities, to innovate new bio-based materials, enhance existing processes, and deepen our comprehension of structure-property relationships within chiral molecules.
Project status (July 2025)
Over the past year and a half, my research at the Weizmann Institute of Science has focused on a fascinating question: how does charge travel through proteins, and how does it affect their function? This process—how activity at one site in a protein can influence another distant site—is known as allosteric regulation.
What makes this project unique is that, instead of focusing only on the usual mechanism (where a small molecule binds to a site on the protein to trigger a shape change), we are exploring how charge itself—without any chemical binding—can regulate protein function. Earlier studies from our group showed that protein activity could be affected by light-triggered charge injection, and my work builds on this discovery to better understand the underlying mechanism.
To do this, I use a well-studied model protein called phosphoglycerate kinase (PGK), which plays a key role in cellular energy metabolism. Its activity can be monitored using standard techniques such as UV-Vis spectroscopy. The key to the experiment is a special light-sensitive tag—a ruthenium (Ru) complex—that can be attached to specific sites on the protein. When illuminated with polarized light, this tag injects charge into the protein.
By placing the tag at different locations on PGK, I can observe how its position affects the protein’s function. Earlier work showed that tagging two different sites led to distinct effects, and interestingly, the changes in activity were only observed with light of a specific polarization.
To carry out these experiments, I developed a semi-automated optical setup that controls both the light exposure and the activity measurements in real time (figure 1). The protein is immobilized on the surface of a custom-built perfusion cell, which is made from a glass slide and a commercial cover well. Silicone tubes are attached at both ends: one connects to a syringe pump that ensures a steady flow with minimal disturbance, and the other to a 3-way valve, allowing us to easily switch between the reaction mixture (used to monitor activity) and a cleaning buffer.
Figure 1. Semi-automated optical setup for light-controlled activity measurements. The system combines a 470 nm light source for charge injection and a deuterium light source for UV-Vis detection, with real-time monitoring performed using a USB 4000 spectrophotometer.
In the next stages of the project, we plan to test more labeling positions and probe how information flows inside the protein in response to localized charge injection. This work addresses a fundamental question in biology: how do proteins sense and respond to internal signals? Gaining insights into this could pave the way for designing new proteins with customized functions—with potential applications in medicine, biotechnology, and synthetic biology.
Oleg Kuliashov – Hebrew University of Jerusalem
Direct measurement of the spin exchange interactions using chiral AFM
Biography
I graduated from Moscow Institute of Physics and Technology with a BS in Physics in 2021 and an MS in Physics in 2023. I worked at the Russian Quantum Center in the Condensed Matter Laboratory on dynamical quantum phase transitions and topological quantum sensors. Currently, I am studying for a Ph.D. in Applied Physics at the Hebrew University of Jerusalem and working at the Quantum Nano Engineering Laboratory. I am interested in the effects of chiral molecules on conventional superconductors.
Doctoral project
I am going to explore and utilize the influence of chemically bonded chiral molecules on conventional superconductors . There is strong evidence that such hybrid materials generate triplet surface superconductivity. Unlike in conventional superconductors where electrons flow in pairs with zero total spin, in triplet superconductors such pairs have a total spin of 1. This is called spin-triplet supercurrent. In my work I will study the effect and use it to develop superconducting interconnects for spin currents.
The surface triplet superconductivity also allows the generation of dissipation-less spin current which may lead to energy-efficient spintronic devices.
I will conduct different types of microscopy experiments on superconductors modified by chiral molecules to elucidate the conditions under which the triplet superconductivity emerges. In the 2nd stage ferromagnets will be used to probe spin-triplet supercurrents that are sensitive to the direction of the ferromagnet’s magnetization. This effect can be used to create magnetic field sensors and magnetic memory elements. To create such a supercurrent, I will make a Josephson junction with a ferromagnetic bridge and superconductors modified by chiral molecules.
Dibyojeet Bagchi – Eindhoven University of Technology
Photo-switching helical materials for chirality-based magnetic memory device
Biography
In 2023, I graduated from the Indian Institute of Technology, Bombay (IIT-B), Mumbai, India with a dual degree (Bachelor plus Master) in chemistry. During my bachelor’s, I worked with Prof. K. P. Kaliappan on the total synthesis of natural products. For my Master’s project, I worked with Prof. Chidambar Kulkarni, and we investigated the effect of n to π* interaction in driving supramolecular assembly. I was also a part of Denmark Technical University briefly as a guest exchange student in the Fall of 2021. In July 2023, I joined the group of Prof. Bert Meijer & Assistant Prof. Ghislaine Vantomme as a PhD Candidate under the Marie Skłodowska Curie Doctoral Network in the “CISSE” project. My project aims to gain more insights into the understanding of CISS effect and apply it for spin control chemistry, and harness novel applications from it.
Doctoral project
Our group previously reported the use of the CISS effect to reduce the hydrogen peroxide formation during the water-splitting reaction. Taking inspiration from the spin control mechanism proposed in the work on water splitting, we plan to study electrochemical carbonyl reduction. Under electrochemical conditions, the carbonyl compound first gets adsorbed on the cathode and undergoes one-electron reduction to form a radical anion which can either lead to alcohol by accepting one more electron or can dimerize to give a pinacol-type product. The product distribution under specific electrochemical conditions is known in the literature for many carbonyls. However, this product distribution can be changed and bias can be shifted from the pinacol to the alcohol by using a chiral material on the cathode, which can act as a spin filter and restrict the radical dimerization. We would also study effect of CISS on enantioselectivity and try to achieve excellent enantiomeric excess values in spin control chemical reactions.
Project status (July 2025)
Supramolecular Polymers as a Tool to Study CISS Effect
Over the past year and a half, my doctoral research has focused on exploring the interface between supramolecular chemistry and spin-selective electron transport—a phenomenon known as the Chiral-Induced Spin Selectivity (CISS) effect. The CISS effect, which describes the ability of chiral molecules to preferentially conduct electrons of a specific spin orientation, has opened new perspectives in enantioselective chemistry, spintronics, and molecular electronics (1). In recent years, supramolecular assemblies have emerged as ideal platforms to study this effect, offering the ability to amplify chirality and control molecular orientation through non-covalent interactions (2-3). Several π-conjugated chiral supramolecular structures have demonstrated enhanced spin polarization due to their ordered architecture (4).The CISS effect has garnered significant interest in recent years due to its potential applications in spintronics, catalysis, and quantum information technologies. However, the precise structural factors governing this effect is not well understood. My project aims to address this knowledge gap by designing novel chiral supramolecular building blocks based on C₃-symmetric molecular frameworks such as truxene, truxanone, and triazatruxene. These rigid, highly symmetrical aromatic cores offer a tunable platform to construct organized, chiral assemblies that can be used to systematically investigate the relationship between molecular structure and spin filtering behavior.
In the early stages of the project, synthetic efforts were directed toward creating a family of C₃-symmetric monomers featuring side chains that promote chiral self-assembly first in solution and then as thin films on electrode surfaces. We successfully synthesized several functionalized derivatives of truxene and truxanone. Then characterized the assembly of these materials using techniques such as circular dichroism (CD) spectroscopy, atomic force microscopy (AFM), and scanning electron microscopy (SEM), confirming their chiral organization at the nanoscale. Several samples were sent to our collaborators in HUJI for spin-selectivity measurements and results are awaited.
The coming phase of the project will focus on expanding this structure–CISS relationship across different classes of C₃-symmetric systems, including nitrogen-rich triazatruxenes, and integrating these insights to develop functional materials for spin-based devices or catalytic platforms. Ultimately, this work contributes to the broader goal of harnessing molecular chirality for controlling electronic spin—a concept that challenges conventional boundaries between chemistry, physics, and materials science.
References
- Bloom B.P., et al. Rev. 2024, 124, 4, 1950–1991
- Mondal AK, et al. J Am Chem Soc, 2021, 143:7189-7195
- Mtangi W., et al. J Am Chem Soc, 2017, 139, 7, 2794–2798
- Kulkarni, C., et al. Adv Materials, 2020, 32(7), 1904965
Ulrich Pototschnig – Hamburg University
First-principles approach to exchange effects in CISS
Biography
When I was still at school, I realized two things: First, I wanted to become a scientist one day. Second, I didn’t want to commit to one subject. It was therefore not a surprise that I decided to study materials science at the University of Leoben, Austria. This gave me new perspectives in various areas such as physics, chemistry and engineering.
After internships at DESY, Max-Planck Institute for Plasma Physics and ESA, I got to know and love an international environment, which is why I applied for an MSCA-position where explores the CISS effect using ab initio computational methods.
My hobbies are not limited to science, I also love hikes, football and old movies. And weekends are often spent at concerts or festivals with friends.
Doctoral project
The origins of the chiral-induced spin selectivity are yet to be fully understood. Present theoretical descriptions still underestimate the effect by several orders of magnitude. Ulrich’s work therefore focuses on investigating the underlying mechanisms using state-of-the-art computational methods based on quantum mechanics, such as density functional theory. My main emphasis is on the so-called exchange interaction which is, for example, responsible for the effect of magnetism.
Berith Pape – Symeres / Eindhoven University of Technology
Spin-induced asymmetric synthesis of chiral scaffolds
Biography
In 2020 I obtained my BSc. degree cum laude in Chemistry from Hanze University of Applied Science. In my final year I performed a one-year internship at Symeres. During this year I worked on the total synthesis of “Rhodomyrtone A & related compound” and “MZ-1, a PROTAC for the degradation of BDR4 protein”. After my graduation, I continued as an associate scientist at Symeres in the medicinal chemistry group. In September 2021 I started my master’s in Organic and Medicinal Chemistry at the University of Gothenburg, where I, during the final year, joined the group of Prof. Leif Eriksson to perform my master thesis in computational drug discovery with as research topic: “Improving proteasome inhibitor effect through adjuvant compounds targeting TSC2-Rheb complex”. I proudly obtained my MSc. degree with honors in June 2023 and in September I started as a doctoral candidate on the MSCA-CISSE project in the group of Prof. Bert Meijer & Ass. Prof. Ghislaine Vantomme hosted by Symeres.
Doctoral project
Electron spin is essential for understanding chemical bonding, nevertheless, it is often presumed that spin control is not relevant in synthetic chemistry due to the small energy associated with spin flipping and that the spin therefore does not contribute significantly to the total angular momentum of molecular collisions. While this may be the case for achiral molecules, chiral molecules and chiral catalysts have shown to exhibit significant spin selectivity. It is assumed that to achieve enantioselectivity in a chemical process a chiral inducer is required, such as a chiral catalyst, chiral solvent, or chiral reactant. In recent years the CISS effect has been demonstrated to possibly be a chiral inducer required for enantioselectivity and consequentially could be employed as a new tool for enantioselective synthesis. These early-stage findings will be the starting point of my project. The work that I will carry out within the MSCA-CISSE consortium will be to explore the use of CISS effect in asymmetric synthesis and assess the application of named in multistep synthesis of industrial relevant molecules.
Kajal Mahadev Katkar – JASCO / Università degli Studi di Brescia
Evaluation of CISS effect on chiroptical response and for chromatographic separation
Biography
I was born in Pune, India in the year 2000. My academic journey commenced with a Bachelor’s degree in Chemistry with Vocational Biotechnology from Fergusson College, affiliated with Pune University from 2017 to 2020. During my bachelor’s, I did an internship at Nawrosjee Wadia College on the project “Synthesis and application of metal nanoparticles using green route”(for 2 months). Then I pursued a master’s degree at the Department of Chemistry, Savitribai Phule Pune University, specializing in Organic Chemistry from 2020 to 2022. I am proud to have secured the first rank in the Organic Chemistry division during my master’s program. My master’s thesis focused on “the synthesis of Deoxynojirimycin—an iminosugar”, a project that significantly honed my research skills. Aside from academics, I actively engaged in various co-curricular activities, recognizing the importance of a well-rounded education.
Post-graduation, I ventured into the industry, joining Aurigene Pharmaceutical Services Pvt. Ltd., a subsidiary of Dr. Reddy’s Laboratory, as a Medicinal Chemist (August 2022 to July 2023). In this role, I actively contributed to multistep organic synthesis, purification of organic compounds, troubleshooting challenges, and interpretation of various analytical data. Eager to broaden my horizons, I transitioned to the CSIR- National Chemical Laboratory, Pune, where I worked as a Project Associate in the Organic Chemistry division on the project “Innovative Processes and Technologies for Crop Protection Chemicals.” I am enthusiastic about the opportunities ahead and look forward to further exploration and growth in the field of Chiral Induced Spin Selectivity Effect.
Doctoral project
The research project is based on the Chiral Induced Spin Selectivity (CISS) Effect which was first described in the year 1999 and this field is expanding very fast. The Chiral induced Spin Selectivity (CISS) Effect refers to the preferred transfer of electrons with one spin orientation over the other while passing through the chiral molecules. This chiral induced spin selectivity has important applications such as improved control of enantioselective reactions, easier separation of enantiomers, and the spintronic devices development. The research thesis aims to focus on two objectives. Firstly, the investigation aims to find correlations between chiroptical responses and CISS effect and furthermore assess if and how the CISS effect alters a molecule’s chiroptical response. At first, chiroptical responses of materials (films) based on a variety of chiral molecules will be measured by using various spectropolarimetric techniques. Then (in collaboration with the Weizmann Institute of Science and the Hebrew University of Jerusalem) the study of the spin polarization of electrons crossing chiral molecules and the resulting transient intramolecular spin polarization of electrons will be conducted. The expected result is a deeper comprehension of how these alterations affect the electric and magnetic dipole transition moments of molecules under evaluation through various spectropolarimetric techniques.
The second objective is to evaluate the applicability of chromatographic enantioseparation on spin-polarised stationary phases. The research will explore the impact of transient intramolecular spin polarization on the adsorption of ferromagnetic substrates. Different types of chiral molecules will be considered for chromatographic separation.
This project will help to determine the importance of chiroptical response onto the CISS effect which is still little known. Moreover, enantioselective chromatographic separation has already demonstrated the potential of CISS effect, especially when working with peptides. Nonetheless, the study aims to assess the applicability and universality of enantio-separation and extend these results to other types of chiral compounds. Since, chiral molecule with one handedness has vital function while its enantiomer may have adverse effect, it is of vital importance to accurately separate both of them. The CISS effect helps the chemical and pharmaceutical industry achieve an inexpensive and generic method for enantiomer separation and large-scale drug purification enabling a future for safe drugs, pesticides, and fertilizers.